The purpose of the study was to develop a Turkish version of the Hypertension Self-care Profile and to examine its reliability and validity. The sample consisted of 200 adults with hypertension. Internal consistency was estimated by calculating the Cronbach alpha coefficient and item-total score correlation regarding item reliability. The test-retest reliability for estimating the stability was estimated using intraclass correlation coefficient. Exploratory factor analysis and confirmatory factor analysis were used for the factor construct validity. Internal consistency reliability coefficients ranged from 0.937 to 0.942. The test-retest reliability was between 0.730 and 0.766. Item-total correlations had a range of 0.491 to 0.758. Single factor with an eigenvalue >1 was extracted for each scale. The Turkish version of the Hypertension Self-care Profile has been successfully translated and cross-culturally adapted to Turkish population.