The inflammatory markers and prognosis of cervicocephalic artery dissection: a stroke center study from a tertiary hospital


Senadim S., Coban E., Tekin B., Balcik Z. E. , Koksal A., Soysal A., ...Daha Fazla

NEUROLOGICAL SCIENCES, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Objective Cervicocephalic artery dissection (CeAD) is the most common cause of ischemic stroke in young adults. Although the exact cause is unknown, inflammation is thought to have a role. Here, we investigated the relationship between CeAD and inflammation. Methods Patients diagnosed with CeAD in our stroke center were evaluated retrospectively, and their demographic and clinical features were recorded. The C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell, neutrophil and lymphocyte counts, platelet/lymphocyte ratio (PLR), and neutrophil/lymphocyte ratio (NLR) were recorded on admission. Modified Rankin scores (mRS) were noted on admission and at 6 months to evaluate the dependency status and functional outcome of each patient. Results Of the 95 patients in the study, 70 (73.7%) were male, and the mean age was 44.4 +/- 9.8 years. Patients with high WBC count, ESR, PLR, and NLR frequently had mRS scores of 3-6 at admission; these differences were significant (p= 0.04,p= 0.02,p= 0.04, andp= 0.02, respectively). At 6 months, patients with high CRP and ESR at admission also had significantly poorer prognoses (p< 0.001,p= 0.002, respectively). PLR and NLR values were higher in patients with mRS of 3-6. But there were no significant differences between the good and poor prognosis groups regarding PLR and NLR (p= 0.22,p= 0.05, respectively). Conclusion Inflammation may have a role in the prognosis of CeAD, and inflammatory markers can be evaluated as auxiliary tests for determining prognosis.