Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells


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Ataseyer-Arslan B., Yilancioglu K., Bekaroglu M. G. , TAŞKIN E. , ALTINÖZ E. , Cetiner S.

GENERAL PHYSIOLOGY AND BIOPHYSICS, cilt.34, ss.201-207, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 34 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4149/gpb_2014034
  • Dergi Adı: GENERAL PHYSIOLOGY AND BIOPHYSICS
  • Sayfa Sayısı: ss.201-207

Özet

Cytotoxic effects of essential oils extracted from Dunaliella sauna on SH-SY5Y human neuroblastoma cells were investigated in this study. GC-MS analysis was used for determination of the composition of essential oils found in Dunaliella salina extract. All experimented concentrations of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells were significantly more cytotoxic than the tested concentrations of the extract on ECV304 human endothelial cells used as a control. Fifthy compounds were detected in GC-MS analysis of the extract, and five major compounds were predominantly found as follows: octadecanoic acid, methyl ester (27.43%); hexadecanoic acid, methyl ester (Cas) methyl palmitate (24.82%); 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (7.39%); octadecanoic acid (5.03%), pentadecanoic acid (3.60%). The cytotoxic activity of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells might be due to high concentrations of octadecanoic acid and hexadecanoic acid. Furthermore, results indicate that the extract demonstrates some proliferative effect on ECV304 cells in a dose-dependent manner between 0.25 and 5 mu g/ml. These results suggest that Dunaliella sauna may have anticancer potential against human neuroblastoma cells.