INVESTIGATION OF DNA BINDING AND CLEAVAGE ACTIVITIES OF BORON COMPLEXES IN THE PRESENCE OF HYDROGEN PEROXIDE


Devrim A. K. , ARSLANTAŞ A. , Sudagidan M., KÖSE D. A. , KARAN B.

STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA, cilt.59, ss.109-118, 2014 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 59 Konu: 3
  • Basım Tarihi: 2014
  • Dergi Adı: STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA
  • Sayfa Sayısı: ss.109-118

Özet

Magnesium [di(hydroxy)mono(citratoborate)]dihydrate (Mg[B(Cit)(OH)(2)](2)center dot 2H2O), Lithium [di(hydroxy)mono(citratoborate)]hydrate Li[B(Cit)(OH)(2)]center dot H2O, Sodium [di(hydroxy)mono(salicylato) borate)hydrate Na[B(Sal)(OH)(2)]center dot H2O and Magnesium[bis(salicylatoborate)]decahydrate Mg[B(Sal)(2)](2)center dot 10H(2)O) complexes have been synthesized and characterized. The cattle genomic DNA (CG-DNA) interaction of the complexes was studied by spectroscopic methods, viscosity, and electrophoresis measurements. The complexes partially intercalated to CG-DNA. Furthermore, DNA cleavage activity of these complexes was also investigated using agarose gel electrophoresis and the complexes show moderate ability of cleavage to the DNA.