© 2021 Elsevier Ltd and Techna Group S.r.l.The major objective of the current review is to highlight the prime importance of bone cements particularly monetite cement as filler to treat various bone defects which may result due to osteoporosis, some accidents, some trauma disease or any other orthopedic surgical disorders. Previous studies showed that polymethyl methacrylate (PMMA), calcium phosphate cements (CPCs), dicalcium phosphate (DCP) cement and acrylic polymer cements have been employed to improve the bone defects, but these materials have a certain issue of in-situ setting. To overcome these problems, concentration was swiftly diverted towards monetite cement which revealed better results. Therefore, in this review, more focus has been given to the monetite cement. In this work, a brief but very productive discussion has also been inducted about the various synthetic routes to synthesize monetite cement and its properties which will help the readers to get key information about the growing significance of monetite cement as a bone filler and its future use and importance. The main theme of this review is to highlight the tremendous achievements achieved in the monetite cementing materials and their further scope in the near future as to upgrade their properties and use in the biomedical field.