Morphometrical Investigation of Effect of Cyclophosphamide On Rat Submandibular Gland


Yahya Zadeh A.

4rd International Medicine and Health Sciences Researches Congress, Çorum, Türkiye, 22 - 23 Ağustos 2020, ss.324-39

  • Basıldığı Şehir: Çorum
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.324-39

Özet

The increasing incidence of cancer disease has raised the use of chemotherapeutic drugs in the recent years. Although cyclophosphamide (SLF) is a highly effective treatment against cancer, it is known to has many side effects. In this study, we investigated morphometric changes caused by SLF in the submandibular glands of 10-12-week-old rats. Fourteen Wistar albino rats were randomly selected and then divided into two groups: control and SLF. Submandibular samples were analysed morphometrically using the stereological method. We found that the number of 325 serous cells was significantly decreased in the SLF group compared to the control group (P < 0.05). The volume of serous acinus and interlobular canals was significantly decreased in the SLF group compared to the control group (P < 0.05). Also, a significant increase in stroma volume was observed in the SLF group compared to the control group (P < 0.05). Our findings showed that SLF had a deleterious effect on the rat submandibular glands, which changed the morphological structure of this organ.