Akademik Veri Yönetim Sistemi
4rd International Medicine and Health Sciences Researches Congress, Çorum, Türkiye, 22 - 23 Ağustos 2020, ss.324-39
The increasing incidence of cancer disease has raised the use of chemotherapeutic
drugs in the recent years. Although cyclophosphamide (SLF) is a highly effective
treatment against cancer, it is known to has many side effects. In this study, we
investigated morphometric changes caused by SLF in the submandibular glands of
10-12-week-old rats. Fourteen Wistar albino rats were randomly selected and then
divided into two groups: control and SLF. Submandibular samples were analysed
morphometrically using the stereological method. We found that the number of
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serous cells was significantly decreased in the SLF group compared to the control
group (P < 0.05). The volume of serous acinus and interlobular canals was
significantly decreased in the SLF group compared to the control group (P < 0.05).
Also, a significant increase in stroma volume was observed in the SLF group
compared to the control group (P < 0.05). Our findings showed that SLF had a
deleterious effect on the rat submandibular glands, which changed the
morphological structure of this organ.