4rd International Medicine and Health Sciences Researches Congress, Çorum, Türkiye, 22 - 23 Ağustos 2020, ss.324-39
The increasing incidence of cancer disease has raised the use of chemotherapeutic
drugs in the recent years. Although cyclophosphamide (SLF) is a highly effective
treatment against cancer, it is known to has many side effects. In this study, we
investigated morphometric changes caused by SLF in the submandibular glands of
10-12-week-old rats. Fourteen Wistar albino rats were randomly selected and then
divided into two groups: control and SLF. Submandibular samples were analysed
morphometrically using the stereological method. We found that the number of
serous cells was significantly decreased in the SLF group compared to the control
group (P < 0.05). The volume of serous acinus and interlobular canals was
significantly decreased in the SLF group compared to the control group (P < 0.05).
Also, a significant increase in stroma volume was observed in the SLF group
compared to the control group (P < 0.05). Our findings showed that SLF had a
deleterious effect on the rat submandibular glands, which changed the
morphological structure of this organ.