This study focuses on how employees’ perceptions of organizational politics affect the perception of workplace friendship. So, an applied research was carried out on 524 employees working at Karabuk University, Teaching and Research Hospital. Hypotheses generated were tested by path analysis under structural equation modeling. In sum, it has been determined that “general political behaviors” have a positive effect on workplace friendship and on the other hand “pay and promotion policies” have a negative effect on workplace friendship. Nevertheless, it has been found that there is no significant effect of the “go along to get ahead behavior” on workplace friendship.