Silver release of Ag (I) doped hydroxyapatite: In vitro study

Erdem U., TÜRKÖZ M. B.

MICROSCOPY RESEARCH AND TECHNIQUE, cilt.82, ss.961-971, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 82 Konu: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/jemt.23243
  • Sayfa Sayıları: ss.961-971


A material is produced by doping of silver (Ag (I)) which has antibacterial property to nano hydroxyapatite (nHAp), to remove the hipersensitivity in the teeth by closing the dentine tubules or dental micro cracks of the teeth and effective against for some bacteria. The doping of Ag (I) can also produces a toxic effect. Ag (I) can be released from the structure as a result of biological, physical and chemical effects and may cause toxicity. Therefore, it is important to determine whether the presence of Ag (I) has a toxic effect. In this study, Ag (I)-doped nHAp was synthesized by precipitation method and tried to determine the release values as a function of time compared to the doping rate by using the ICP-OES. Also, the products we produce in simulated body fluid were kept for retention periods of 4-20 weeks to determine degradation percentages. A cytotoxicity study was performed to observe the toxic effect that may be caused by possible Ag (I) release. According to the analysis, the release values in all products were observed in ppb level. And it is concluded that the materials produced are not degraded. Cell viability values of more than 70% were obtained. It was observed that the release of Ag (I) bound to Ag (I)-doped nHAp hexagonal structure was very low. It was concluded that the products are not degraded and Ag (I)-doped nHAp to a certain ratio is a biocompatible material that can be used in dentistry for treatment.