Novel 2-amino-1,3,4-thiadiazoles and their acyl derivatives: Synthesis, structural characterization, molecular docking studies and comparison of experimental and computational results


ER M. , Isildak G., TAHTACI H. , KARAKURT T.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1110, ss.102-113, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 1110
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.molstruc.2016.01.045
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Sayfa Sayıları: ss.102-113

Özet

This study aims to synthesize and characterize compounds containing 2-amino-1,3,4-thiadiazole and compare experimental results to theoretical results. For this purpose, firstly mono, di and tetra 2-amino-1,3,4-thiadiazole compounds (2a-c, 14, 20 and 25) were synthesized in relatively high yields (74-87%). The target compounds (3-11, 15-17, 21-23 and 26-28) were then synthesized in moderate to high yields (65-85%) from the reactions of 2-amino-1,3,4-thiadiazole compounds with various acyl chloride derivatives.