Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples


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Savage J. E. , Salvatore J. E. , Aliev F., Edwards A. C. , Hickman M., Kendler K. S. , et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, cilt.42, ss.520-530, 2018 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 42 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/acer.13589
  • Dergi Adı: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
  • Sayfa Sayısı: ss.520-530

Özet

BackgroundDespite consistent evidence of the heritability of alcohol use disorders (AUDs), few specific genes with an etiological role have been identified. It is likely that AUDs are highly polygenic; however, the etiological pathways and genetic variants involved may differ between populations. The aim of this study was thus to evaluate whether aggregate genetic risk for AUDs differed between clinically ascertained and population-based epidemiological samples.