A Comparative Study on DNA Binding Properties of 2,10,16,24-Tetrakis 4-(4-hydroxyphenyl)-1-phenylethyl) phenoxy)-Substituted Co(II) and Mg(II) Phthalocyanine Compounds


ARSLANTAŞ A. , Ağırtaş M. S.

CHEMISTRYSELECT, cilt.2, ss.8661-8665, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 2 Konu: 27
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/slct.201701224
  • Dergi Adı: CHEMISTRYSELECT
  • Sayfa Sayısı: ss.8661-8665

Özet

In this study, DNA binding properties of 2,10,16,24-tetrakis4-(4-hydroxyphenyl)-1-phenylethyl)phenoxy)phthalocyaninato Co(II) and Mg(II) compounds were analyzed. CT-DNA was used to determine DNA binding properties of Co(II) (4) and Mg(II) (5) phthalocyanine compounds. The DNA binding properties of compounds 4 and 5 were investigated using electronic absorption titration, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation study, electrophoresis and viscosity measurements in Tris-buffer (pH 7.0). The results indicated that Co(II) and Mg(II) phthalocyanine compounds have strong affinity for CT-DNA through intercalation.