Investigation of DNA-Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5-Trimethoxybenzyloxy Substituents


ARSLANTAŞ A. , Ağırtaş M. S.

CHEMISTRYSELECT, cilt.2, ss.11659-11665, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 2 Konu: 35
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/slct.201702362
  • Dergi Adı: CHEMISTRYSELECT
  • Sayfa Sayıları: ss.11659-11665

Özet

In this study, DNA-binding activities of previously synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanine compounds with CT-DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris-HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT-DNA via intercalation binding mode.