A Brief Critique of the TATES Procedure

Aliev F., Salvatore J. E. , Agrawal A., Almasy L., Chan G., Edenberg H. J. , ...Daha Fazla

BEHAVIOR GENETICS, cilt.48, ss.155-167, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 48 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s10519-018-9890-6
  • Sayfa Sayıları: ss.155-167


The Trait-based test that uses the Extended Simes procedure (TATES) was developed as a method for conducting multivariate GWAS for correlated phenotypes whose underlying genetic architecture is complex. In this paper, we provide a brief methodological critique of the TATES method using simulated examples and a mathematical proof. Our simulated examples using correlated phenotypes show that the Type I error rate is higher than expected, and that more TATES p values fall outside of the confidence interval relative to expectation. Thus the method may result in systematic inflation when used with correlated phenotypes. In a mathematical proof we further demonstrate that the distribution of TATES p values deviates from expectation in a manner indicative of inflation. Our findings indicate the need for caution when using TATES for multivariate GWAS of correlated phenotypes.