Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations


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Mathies L. D. , Aliev F., Davies A. G. , Dick D. M. , Bettinger J. C.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, cilt.41, ss.2033-2040, 2017 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 41 Konu: 12
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/acer.13514
  • Dergi Adı: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
  • Sayfa Sayısı: ss.2033-2040

Özet

BackgroundTesting for direct gene or single nucleotide polymorphism replication of association across studies may not capture the true importance of a candidate locus; rather, we suggest that relevant replication across studies may be found at the level of a biological process. We previously observed that variation in 2 members of the switching defective/sucrose nonfermenting (SWI/SNF) chromatin remodeling complex is associated with alcohol dependence (AD) in the Irish Affected Sib Pair Study for Alcohol Dependence. Here, we tested for association with alcohol-related outcomes using a set of genes functioning in the SWI/SNF complex in 2 independent samples.