DNA Binding and Cleavage Activities of Na[B(Glu)(OH)(2)]center dot 2H(2)O, Na[B(Cit)(OH)(2)]center dot 2H(2)O, Li[B(Sal)(OH)(2)], and Mg[B(Sal)(OH)(2)]center dot 2H(2)O Complexes


Arslantas A., Devrim A. K. , Sudagidan M., Kose D. A.

JOURNAL OF CHEMISTRY, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası:
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1155/2013/406161
  • Dergi Adı: JOURNAL OF CHEMISTRY

Özet

The interaction of some previously reported complexes Na[B(Glu)(OH)(2)]center dot 2H(2)O, Na[B(Cit)(OH)(2)]center dot H2O, Li[B(Sal)(OH)(2)], and Mg[B(Sal)(OH)(2)]center dot 2H(2)O with cattle genomic DNA (CG-DNA) was investigated using UV absorption, viscosity measurements, and fluorescence studies. These complexes interact with DNA through the intercalative mode of binding. In addition, the DNA cleavage activity of the complexes in presence of H2O2 was determined using agarose gel electrophoresis. All complexes exhibit moderate ability of cleavage to the DNA.