The Reverse Osmosis systems which are widely used in seawater and brackish water may have economically advantages but if it is used efficiently during the working of useful membranes life. The organic and the inorganic contaminants which is in the reverse osmosis feed flow occasionally cause the plug of the surface of the membranes. It's encountered soon or later this situation effects the system of the reverse osmosis productivity negatively. The applications which are done in a better way of the pre-treatment and pre-conditioning is not enough to overcome the plug but put back the formation process. It's necessary to clean the membranes with using suitable methods and suitable chemicals to cure the plug. In the present study, it's aimed to evaluate the negative effects of chemicals using in order to clean polyamide membranes and cleaning procedures. Through the aim of the present study, the membranes problems that are inorganic fouling and biofilms cleaning procedures involving polyamide membranes limited values of chemicals are dealt together. As results of evaluations, it's understood that for necessity of efficient cleaning acidic and alkaline chemicals take an important part cause shortening the efficient usage life.