Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems


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Salvatore J. E. , Savage J. E. , Barr P., Wolen A. R. , Aliev F., Vuoksimaa E., ...Daha Fazla

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, cilt.42, ss.413-423, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/acer.13551
  • Dergi Adı: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
  • Sayfa Sayıları: ss.413-423

Özet

BackgroundCharacterizing aggregate genetic risk for alcohol misuse and identifying variants involved in gene-by-environment (GxE) interaction effects has so far been a major challenge. We hypothesized that functional genomic information could be used to enhance detection of polygenic signal underlying alcohol misuse and to prioritize identification of single nucleotide polymorphisms (SNPs) most likely to exhibit GxE effects.