Evaluation of multidrug resistance-1 gene C > T polymorphism frequency in patients with asthma

Toru U., AYADA C., Genc O., Yasar Z., Sahin S., TAŞKIN E. , et al.

CLINICS, cilt.70, ss.670-674, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 70 Konu: 10
  • Basım Tarihi: 2015
  • Doi Numarası: 10.6061/clinics/2015(10)02
  • Dergi Adı: CLINICS
  • Sayfa Sayısı: ss.670-674

Özet

OBJECTIVES: Asthma is a chronic inflammatory lung disease characterized by bronchial hyperresponsiveness and airflow obstruction. Genetic and oxidative stress factors, in addition to pulmonary and systemic inflammatory processes, play a pivotal role in the pathogenesis of asthma. The products of the multidrug resistance-1 gene protect lung tissue from oxidative stress. Here, we aimed to evaluate the association between the multidrug resistance-1 gene C>T polymorphism and asthma with regard to oxidative stress-related parameters of asthmatic patients.